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ZURICH, April 18 Novartis's push into oncology and liver disease, two of its treatment priorities, advanced on Monday as the Swiss drugmaker won a second U.S. breakthrough tag for its cancer gene therapy while striking a separate pact with Allergan.
The Basel-based drugmaker's chimeric antigen receptor therapy (CAR-T) treatment, called CTL019, was awarded the U.S. Food and Drug Administration's breakthrough therapy designation for adults with relapsed/refractory (r/r) diffuse large B-cell lymphoma, a common blood cancer.
Novartis also said it will combine one of its investigational drugs with Allergan's cenicriviroc in a mid-stage trial against liver disease known as non-alcoholic steatohepatitis, or NASH, that is growing more prevalent due in large part to obesity.
Novartis's drug development head Vas Narasimhan has highlighted oncology and NASH as two pillars of his strategy to ensure growth. Narasimhan expects CTL019 to eventually top $1 billion in sales for multiple cancer types and also has high hopes for his NASH treatments, in particular in concert with other companies.
"Collaboration is key to developing the best possible treatments that are urgently needed for NASH patients," Narasimhan said in a statement.
Late last year, Novartis struck a $50 million licensing deal with Conatus Pharmaceuticals for a separate treatment for NASH, an area that has also been tagged as a focus by industry rivals including Gilead and Bristol-Myers Squibb.
CTL019 previously won accelerated FDA review for treating young people with acute lymphoblastic leukaemia (ALL).
Last month, Novartis submitted CTL019 for FDA review in young ALL patients as it races rivals including Kite Pharma to become the first to secure regulators' approval for a CAR-T treatment, where T cells are removed from patients, re-engineered to fight their cancers, then reinfused. (Reporting by John Miller; Editing by Tom Heneghan)
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