BRIEF-Karyopharm says top-line data from SADAL study expected in second half of 2018
* Karyopharm reports updated Phase 2b SADAL data for Selinexor in diffuse large B-cell lymphoma at the 2017 European Hematology Association Annual Meeting
* Talks over settlement with hold-out shareholder group
* Four groups have settled with RBS over 2008 cash call
* Case scheduled to come to court in May
By Andrew MacAskill and Kirstin Ridley
LONDON, March 17 Lawyers representing tens of thousands of Royal Bank of Scotland shareholders have held tentative talks to settle a 1.2 billion pound ($1.5 billion) damages claim over the lender's 2008 rights issue that was launched shortly before a state bailout, two sources said.
The two sources, who are familiar with the situation, said RBS and the RBoS Shareholder Action group, which includes 27,000 private investors, former and current RBS staff and about 100 institutions, had discussed an out-of-court deal.
But in a move highlighting the difficulties of rallying such a vast group -- the last of five shareholder claims yet to settle with the bank -- one source warned that some retail investors were determined to take the case to trial in May.
A settlement would end one of the most complex and costly litigation battles in English legal history.
It would also spare RBS, which is still more than 70 percent owned by the state, a lengthy and potentially embarrassing court case that would put its disgraced former chief executive Fred Goodwin and other former senior staff in the witness box.
RBS last year struck an out-of-court deal with four other investor groups, who also accused the bank of omissions and misrepresentations about its financial strength when it launched the 12 billion pound rights issue at the height of the credit crisis.
But the RBoS Shareholder Action Group rejected its share of RBS's 800 million pound offer.
RBS, which has said it would welcome a deal with the action group, declined to comment on any talks. When asked by Reuters at the end of February, Chief Executive Ross McEwan there had been "some conversations" but no resolution.
RBoS Shareholder Action Group declined to comment, while Signature Litigation, the legal firm representing the claimants, referred requests to the action group.
The bank has been applying pressure on the shareholder group, which has been questioned persistently about the adequacy of its funding, switched legal teams three times and saw some institutions break away in 2015 to launch separate litigation.
In a move described as bullying by claimants, the group was forced to reveal the names of its latest third-party litigation funders after RBS asked for details of its After The Event (ATE) insurance while threatening to file an application for security for costs.
ATE insurance policies cover the risk of losing and paying the other side's costs in litigation.
Last week, High Court Judge Robert Hildyard also warned claimants against the "serious consequences" of a funding gap or shortfall. He was also "increasingly troubled" by inconsistent statements about ATE cover and other statements by the group.
The action group has told the court that its current third-party litigation funders include asset recovery and private equity firm Hunnewell Partners (BVI), which says on its website it has a separate and ring-fenced litigation funding business.
Hunnewell, which did not respond to requests for comment, is not listed as a member of the Association of Litigation Funders, an independent body that ensures members abide by a code of conduct and maintains a complaints handling procedure.
RBS has estimated its legal costs, from the December settlements to the end of the May trial, at 25 million pounds.
Shareholders lost around 80 percent of their investments when RBS collapsed just months after the 2008 cash call, forcing the government to step in with a 45 billion pound-plus bailout.
Former RBS chief executive Goodwin was stripped of his knighthood but kept an annual pension of 342,500 pounds. ($1 = 0.8160 pounds) (Editing by Keith Weir)
* Analysts say internet companies can adjust to new rules (Recasts, adds context, analyst comment, user comments)
LONDON, June 23 Investors pulled $7.7 billion from U.S. equities, the biggest outflows in five weeks, data from Bank of America Merrill Lynch (BAML) showed on Friday, reversing the previous week's bumper inflows as bears battled with the bulls.