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UPDATE 2-S.Korea to begin producing Novavax COVID-19 vaccine as early as June

* Five local companies aim for Phase III trials this year

* Domestic Novavax shot production as early as June

* Restrictions introduced as fears of fourth wave grow (Adds quotes, new case numbers, background)

SEOUL, April 12 (Reuters) - South Korea said on Monday it plans to begin local production of Novavax Inc’s COVID-19 vaccine as early as June, while five domestic companies aim to start late stage clinical trials of their own shots in the second half of this year.

The announcements came after President Moon Jae-in hosted a special meeting on anti-virus efforts and vaccine development as the country fears a possible fourth wave of infections.

Health Minister Kwon Deok-cheol said that SK Bioscience Co will be able to begin manufacturing Novavax COVID-19 vaccines as early as June and could supply as many as 20 million doses by the end of third quarter.

The U.S. drugmaker signed a licence agreement with SK Bioscience to produce 40 million doses of its COVID-19 vaccine for South Korea.

“We would be able to secure vaccines in a more stable manner if domestic production begins, given growing supply uncertainty around the world,” he told a briefing.

South Korea began its inoculation campaign in late February, aiming to reach herd immunity for its 52 million population by November.

The health ministry also said five local companies were aiming to start Phase III trials of their own vaccines later this year - SK Bioscience, EuBiologics Co, Cellid Co , Genexine Inc and GeneOne Life Science .

The government plans to provide 68.7 billion won ($61.1 million) to support the companies’ vaccine development, the ministry said in a statement.

The Korea Disease Control and Prevention Agency (KDCA) reported 587 new COVID-19 cases as of Sunday, marking a slight drop due to fewer tests being carried out over the weekend after the daily tally hovered above 600 for six straight days.

Authorities have reimposed a ban on nightclubs, karaoke bars and other nightly entertainment facilities, effective from Monday, as clusters of the virus continue to emerge from small gatherings, mostly in the greater Seoul area.

Total infections rose to 110,146, with 1,770 deaths. ($1 = 1,125.2100 won) (Reporting by Hyonhee Shin Editing by Catherine Evans and David Goodman and Kirsten Donovan)

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