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* U.S. says tariff hikes go live at 12:01 a.m. on Friday
* China vows unspecified retaliation
* All major S&P sectors decline; tech most hit
* Tapestry gains after quarterly profit beat
* Indexes down: Dow 0.95%, S&P 0.97%, Nasdaq 1.18% (Updates prices to open)
By Shreyashi Sanyal and Amy Caren Daniel
May 9 (Reuters) - U.S. stocks tumbled on Thursday, with focus on a high-stakes meeting between the United States and China that could decide the fate of a long-awaited trade deal, even as additional tariffs on Chinese goods loomed.
Trump vowed not to back down on imposing new tariffs unless Beijing "stops cheating our workers", as two-day talks begin in Washington on Thursday.
China has threatened to retaliate if tariffs on $200 billion worth of Chinese goods increase to 25% on Friday, rekindling worries of a global economic slowdown and triggering flight to safety among investors.
"It is a concerning feeling for investors because they don't know what to make of these conflicting signals from trade talks," said Rick Meckler, partner at Cherry Lane Investments in New Vernon, New Jersey.
"There isn't really a lot of precedent for what Trump is doing here but the general view is that he does want an agreement. The talks aren't dead and there is potential that they might still reach an agreement."
The benchmark S&P 500 index fell below its 50-day moving average, a closely watched level of near-term momentum, with all the major sectors lower.
The technology sector posted the steepest declines, slipping 1.58%, dragged down by a fall in shares of iPhone maker Apple Inc and chipmakers, which get a large portion of their revenue from China.
The Philadelphia chip index declined 2.25%, also pressured by a modest profit growth forecast from Intel. The index has fallen 7.6% so far this week, and is on pace to post its biggest percentage weekly loss since January 2016.
Trade-sensitive industrial bellwethers were also hit, with Boeing Co, Caterpillar Inc and 3M Co trading down 1%.
Meanwhile, data showed U.S. goods trade deficit with China, a focus of the Trump administration's "America First" agenda, dropped to a five-year low in March amid a surge in exports, including soybeans.
The CBOE Volatility Index, a gauge of investor anxiety, spiked to its highest level in four months.
At 9:43 a.m. ET, the Dow Jones Industrial Average was down 245.57 points, or 0.95%, at 25,721.76. The S&P 500 was down 27.83 points, or 0.97%, at 2,851.59 and the Nasdaq Composite was down 93.95 points, or 1.18%, at 7,849.37.
In a bright spot, Tapestry Inc jumped 11.3%, the most among S&P companies, after the Coach handbag maker beat quarterly profit estimates and announced a $1 billion share buyback program.
Chevron Corp climbed 2.9%, and was the biggest boost to the Dow, after the oil major said it would not raise its $33 billion offer to buy Anadarko Petroleum Corp.
Declining issues outnumbered advancers for a 3.83-to-1 ratio on the NYSE and for a 3.45-to-1 ratio on the Nasdaq.
The S&P index recorded no new 52-week high and eight new lows, while the Nasdaq recorded 13 new highs and 43 new lows. (Reporting by Shreyashi Sanyal and Amy Caren Daniel in Bengaluru; Editing by Sriraj Kalluvila)