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* Fed policy decision expected at 2:00 p.m. ET
* FedEx tumbles after profit warning; drags down UPS shares
* Adobe down after tepid revenue forecast
* Indexes down: Dow 0.21%, S&P 0.27%, Nasdaq 0.39% (Updates to early afternoon)
By Medha Singh and Ambar Warrick
Sept 18 (Reuters) - U.S. stocks came under pressure on Wednesday as investors waited for the Federal Reserve's decision on interest rates and clues about its future monetary policy, while a profit warning by FedEx weighed on sentiment.
The package delivery company's shares tumbled 13.6% and were on course for their sharpest one-day percentage drop since the financial crisis after FedEx blamed U.S.-China trade tensions and a split with Amazon.com Inc for its dismal full-year profit forecast.
Its stock was the biggest drag on the S&P 500 index and drove a 1.7% drop in shares of rival United Parcel Service Inc.
The Dow Jones Transport Average lost 1.71%, while the broader industrial sector was off 0.65%. Ten of the 11 major S&P sectors were in the red.
Investors are now squarely focused on the U.S. central bank's policy statement due at 2:00 p.m. ET (1800 GMT), followed by Chair Jerome Powell's address a half hour later.
The Fed is expected to lower interest rates by a quarter percentage point for the second time in three months, but a deep divide among policymakers has led traders to abandon all bets on a third reduction this year.
"I expect them to give a tone of 'we'll let the number tell us what to do next' as they have in the past," said JJ Kinahan, chief market strategist at TD Ameritrade in Chicago.
"Especially, with three of the Fed board members last time not voting for the rate cut, you may see even more cautious language going forward."
Earlier in the day, the central bank injected more cash into the banking system as the key interest rate pierced above its targeted range for the first time since the financial crisis. That puts pressure on policymakers to come up with long-term fixes for the funding squeeze.
In response, trader bets for a 25 basis point reduction in interest rates shot back up to 72.7% after falling to nearly 50% on Tuesday, according to CME Group's FedWatch tool.
The interest-rate sensitive banking index edged 0.10% lower and was on pace for a third day of losses.
Expectations of lower rates have spurred a Wall Street rally this year, with the benchmark S&P 500 now less than 1% below its all-time high hit in July.
At 12:37 p.m. ET, the Dow Jones Industrial Average was down 55.89 points, or 0.21%, at 27,054.91, the S&P 500 was down 8.08 points, or 0.27%, at 2,997.62. The Nasdaq Composite was down 31.90 points, or 0.39%, at 8,154.12.
Adobe Inc slipped 2.8% after the Photoshop software maker forecast tepid revenue for the current quarter.
In a bright spot, Versace-owner Capri Holdings Ltd rose 1.9% as Jefferies raised its price target on the stock.
Declining issues outnumbered advancers for a 1.51-to-1 ratio on the NYSE and a 1.84-to-1 ratio on the Nasdaq.
The S&P index recorded 15 new 52-week highs and one new low, while the Nasdaq recorded 36 new highs and 27 new lows. (Reporting by Medha Singh and Ambar Warrick in Bengaluru; Editing by Anil D'Silva)